| NGF |
| LOCUS ID | 4803 | ||||||
| GENE_SYMBOL | NGF | ||||||
| GENE NAME | nerve growth factor (beta polypeptide) | ||||||
| SYNONYMNS | NGFB, HSAN5, Beta-NGF | ||||||
| CHROMOSOME | 1 | ||||||
| HOMOLOGENE ID | 1876 | ||||||
| SOURCE | RAT |
| PMIDs | 22928161 |
| GENE SUMMARY |
|---|
| This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008] |
| OBSERVATION |
|---|
| 1. Available literature on the role of NGF on diabetic wound healing is sparse but encouraging. Exogenous supplementation of NGF or the use of alternative techniques to increase its endogenous expression could emerge as a protective and therapeutic modality for diabetic foot ulcers in addition to standard treatment and other growth factors. |