| NPY |
| LOCUS ID | 4852 | ||||||
| GENE_SYMBOL | NPY | ||||||
| GENE NAME | neuropeptide Y | ||||||
| SYNONYMNS | PYY4 | ||||||
| CHROMOSOME | 7 | ||||||
| HOMOLOGENE ID | 697 | ||||||
| SOURCE | HUMAN |
| PMIDs | 22029806 |
| GENE SUMMARY |
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| This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes including cortical excitability stress response food intake circadian rhythms and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase activate mitogen-activated protein kise (MAPK) regulate intracellular calcium levels and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the sigl peptide is associated with elevated cholesterol levels higher alcohol consumption and may be a risk factor for various metabolic and cardiovascular diseases. [provided by RefSeq Nov 2009] |
| OBSERVATION |
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| 1. These results demonstrate that the expression of neuropeptides and their receptors in the diabetic heart is significantly impaired, and may be the link between neuropathy and cardiac complications. Further studies are warranted to delineate pathophysiologic mechanisms associated with dysregulation of the cardiac neuropeptide system and the relationship to cardiac complications in diabetes. NPY2R and NPY5R exert a protective effect in the heart, any change, especially a reduction in NPY2R and NPY5R expression may alter the ventricular function. |