| PECAM1 |
| LOCUS ID | 5175 | ||||||
| GENE_SYMBOL | PECAM1 | ||||||
| GENE NAME | platelet and endothelial cell adhesion molecule 1 | ||||||
| SYNONYMNS | CD31, PECA1, GPIIA', PECAM-1, endoCAM, CD31/EndoCAM | ||||||
| CHROMOSOME | 17 | ||||||
| HOMOLOGENE ID | 47925 | ||||||
| SOURCE | HUMAN |
| PMIDs | 24624298 |
| GENE SUMMARY |
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| The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010] |
| OBSERVATION |
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| 1. CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a 140?kDa type I transmembrane glycoprotein that is expressed at high levels on early and mature endothelial cells as in capillary microcirculation, but also in human bone marrow stem cells. CD34+KDR+ and CD31+133+ EPC differentiation could have a prognostic and therapeutic significance in the healing process of neuropathic and neuroischemic lesions. |