| TH |
| LOCUS ID | 7054 | ||||||
| GENE_SYMBOL | TH | ||||||
| GENE NAME | tyrosine hydroxylase | ||||||
| SYNONYMNS | TYH DYT14 DYT5b | ||||||
| CHROMOSOME | 11 | ||||||
| HOMOLOGENE ID | 307 | ||||||
| SOURCE | RATS |
| PMIDs | 24356397 |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATION |
|---|
| 1. In the DS group, the tyrosine hydroxylase (TH) and NGF expression were significantly lower than in the other groups, and significant proximal-distal heterogeneities existed regarding the TH and NGF expression in the left ventricle, but were markedly repaired in the DN group. |