| TRPV4 |
| LOCUS ID | 59341 | ||||||
| GENE_SYMBOL | TRPV4 | ||||||
| GENE NAME | transient receptor potential cation channel, subfamily V, member 4 | ||||||
| SYNONYMNS | SMAL VRL2 BCYM3 CMT2C SPSMA TRP12 VROAC HMSN2C OTRPC4 SSQTL1 | ||||||
| CHROMOSOME | 12 | ||||||
| HOMOLOGENE ID | 11003 | ||||||
| SOURCE | RATS |
| PMIDs | 18234883 |
| GENE SUMMARY |
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| This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] |
| OBSERVATION |
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| 1. Furthermore, we establish a direct interaction between TRPV4, alpha2 integrin, and the Src tyrosine kinase Lyn in sensory neurons. We suggest that TRPV4 plays a role in mechanotransduction, as a component of a molecular complex that functions only in the setting of inflammation or nerve injury. |