| HNF1B |
| LOCUS ID | 6928 |
| GENE_SYMBOL | HNF1B |
| GENE NAME | HNF1 homeobox B |
| SYNONYMNS | FJHN,HNF2,LFB3,TCF2,HPC11,LF-B3,MODY5,TCF-2,VHNF1, |
| CHROMOSOME | 17 |
| HOMOLOGENE ID | 396 |
| GENE SUMMARY |
|---|
| This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to D as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in rel cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |