| MAP3K1 |
| LOCUS ID | 4214 |
| GENE_SYMBOL | MAP3K1 |
| GENE NAME | mitogen-activated protein kinase kinase kinase 1 |
| SYNONYMNS | MEKK,MEKK1,SRXY6,MEKK,1,MAPKKK1 |
| CHROMOSOME | 5 |
| HOMOLOGENE ID | 8056 |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] |