| MMP9 |
| LOCUS ID | 4318 |
| GENE_SYMBOL | MMP9 |
| GENE NAME | matrix metallopeptidase 9 (gelatise B 92kDa gelat |
| SYNONYMNS | GELB, CLG4B, MMP-9, MANDP2 |
| CHROMOSOME | 20 |
| HOMOLOGENE ID | 3659 |
| GENE SUMMARY |
|---|
| Proteins of the matrix metalloproteise (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development reproduction and tissue remodeling as well as in disease processes such as arthritis and metastasis. Most MMP's are secreted as ictive proproteins which are activated when cleaved by extracellular proteises. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq Jul 2008] |