PTEN
LOCUS ID5728
GENE_SYMBOLPTEN
GENE NAMEphosphatase and tensin homolog
SYNONYMNSBZS, DEC, CWS1, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10
CHROMOSOME10
HOMOLOGENE ID265
GENE SUMMARY
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB sigling pathway. [provided by RefSeq, Jul 2008]