RAPGEF1
LOCUS ID2889
GENE_SYMBOLRAPGEF1
GENE NAMERap guanine nucleotide exchange factor 1
SYNONYMNSC3G,GRF2
CHROMOSOME9
HOMOLOGENE ID50501
GENE SUMMARY
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]