SGCG
LOCUS ID6445
GENE_SYMBOLSGCG
GENE NAMEsarcoglycan gamma
SYNONYMNSA4,MAM,DMDA,SCG3,35DAG,DAGA4,DMDA1,LGMD2C,SCARMD2,
CHROMOSOME13
HOMOLOGENE ID194
GENE SUMMARY
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]