Go to Advanced Search
SGCG |
LOCUS ID | 6445 |
GENE_SYMBOL | SGCG |
GENE NAME | sarcoglycan gamma |
SYNONYMNS | A4,MAM,DMDA,SCG3,35DAG,DAGA4,DMDA1,LGMD2C,SCARMD2, |
CHROMOSOME | 13 |
HOMOLOGENE ID | 194 |
GENE SUMMARY |
---|
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008] |