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STK11 |
LOCUS ID | 6794 |
GENE_SYMBOL | STK11 |
GENE NAME | serine/threonine kise 11 |
SYNONYMNS | PJS, LKB1, hLKB1 |
CHROMOSOME | 19 |
HOMOLOGENE ID | 393 |
GENE SUMMARY |
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This gene, which encodes a member of the serine/threonine kise family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal domint disorder characterized by the growth of polyps in the gastrointestil tract, pigmented macules on the skin and mouth, and other neoplasms. Alterte transcriptiol splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |