| ADCYAP1 |
| LOCUS ID | 116 | ||||
| GENE_SYMBOL | ADCYAP1 | ||||
| GENE NAME | adenylate cyclase activating polypeptide 1 (pituitary) | ||||
| SYNONYMNS | PACAP | ||||
| CHROMOSOME | 18 | ||||
| HOMOLOGENE ID | 869 | ||||
| SOURCE | RAT |
| PMIDs | 22350850, 24262293 |
| GENE SUMMARY |
|---|
| This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013] |
| OBSERVATION |
|---|
| 1. These suggest that PACAP has a therapeutic potential in diabetic retinopathy. 2. Inhibition of apoptosis is one of the PACAP-induced pathways with therapeutic potential in early experimental diabetic retinopathy. |