ADCYAP1
LOCUS ID116
GENE_SYMBOLADCYAP1
GENE NAMEadenylate cyclase activating polypeptide 1 (pituitary)
SYNONYMNSPACAP
CHROMOSOME18
HOMOLOGENE ID869
SOURCERAT
PMIDs22350850, 24262293
GENE SUMMARY
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

OBSERVATION
1. These suggest that PACAP has a therapeutic potential in diabetic retinopathy. 2. Inhibition of apoptosis is one of the PACAP-induced pathways with therapeutic potential in early experimental diabetic retinopathy.