| NME2 |
| LOCUS ID | 4831 | ||||
| GENE_SYMBOL | NME2 | ||||
| GENE NAME | NME/NM23 nucleoside diphosphate kinase 2 | ||||
| SYNONYMNS | PUF, NDKB, NDPKB, NM23B, NDPK-B, NM23-H2 | ||||
| CHROMOSOME | 17 | ||||
| HOMOLOGENE ID | 133879 | ||||
| SOURCE | MICE |
| PMIDs | 25900369 |
| GENE SUMMARY |
|---|
| Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple altertively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates turally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] |
| OBSERVATION |
|---|
| 1. Our data identify NDPKB as a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway. |