A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
                                                                                                                    Go to Advanced Search
RBP4 |
LOCUS ID | 5950 | ||||
GENE_SYMBOL | RBP4 | ||||
GENE NAME | retinol binding protein 4, plasma | ||||
SYNONYMNS | RDCCAS, MCOPCB10 | ||||
CHROMOSOME | 10 | ||||
HOMOLOGENE ID | 4908 | ||||
SOURCE | HUMAN |
PMIDs | 20233518 |
GENE SUMMARY |
---|
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008] |
OBSERVATION |
---|
1. This study showed that RBP4 may be involved in the process of diabetic retinopathy and may be a novel biomarker for its diagnosis and treatment in diabetic patients. |