| SYVN1 |
| LOCUS ID | 84447 | ||||
| GENE_SYMBOL | SYVN1 | ||||
| GENE NAME | synoviolin 1 | ||||
| SYNONYMNS | DER3, HRD1 | ||||
| CHROMOSOME | 11 | ||||
| HOMOLOGENE ID | 32700 | ||||
| SOURCE | MICE |
| PMIDs | 26358086 |
| GENE SUMMARY |
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| This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additiol degradation of unfolded proteins. Sequence alysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011] |
| OBSERVATION |
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| 1.Previously, we identified Hmg CoA reductase degradation protein 1 (SYVN1) as a putative DR protective gene via gene expression analysis. Compared with diabetic WT mice, diabetic SYVN1 mice had significantly more cells and reduced apoptosis in the retinal ganglion layer. Retinal vascular leakage was significantly lower in diabetic SYVN1 mice than in diabetic WT mice. Thus, these results strongly supported our hypothesis that SYVN1 confers DR resistance. |