| ABCC8 |
| LOCUS ID | 6833 | ||||||||||
| GENE_SYMBOL | ABCC8 | ||||||||||
| GENE NAME | ATP binding cassette | ||||||||||
| SYNONYMNS | HI,SUR,HHF1,MRP8,PHHI,SUR1,ABC36,HRINS,TNDM2,SUR1delta2 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 68048 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficie |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. Sulfonylureas are insulin secretagogues which act in pancreatic ? cells by blocking the KATP channels encoded by KCNJ11 and ABCC8 genes. | 29396966 |