| ABCG1 |
| LOCUS ID | 9619 | |||||||||||||
| GENE_SYMBOL | ABCG1 | |||||||||||||
| GENE NAME | ATP binding cassette | |||||||||||||
| SYNONYMNS | ABC8, WHITE1 | |||||||||||||
| CHROMOSOME | 21 | |||||||||||||
| HOMOLOGENE ID | 21022 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Strategies to upregulate ABCG1 expression and function in type 2 diabetes mellitus could have therapeutic potential for limiting the accelerated vascular disease observed in patients with type 2 diabetes mellitus. | 18490524 |
| Atherosclerosis | 1. ABCG1 plays a major role in macrophage cholesterol efflux and that decreased ABCG1 function can facilitate foam cell formation in Type 2 diabetic mice. | 16723355 |