| ABHD5 |
| LOCUS ID | 51099 | ||||||||||
| GENE_SYMBOL | ABHD5 | ||||||||||
| GENE NAME | abhydrolase domain c | ||||||||||
| SYNONYMNS | CGI58 IECN2 NCIE2 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 41088 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired lon |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Macrophage-specific CGI-58 knockout (MaKO) in mice aggravates HFD-induced glucose intolerance and IR, which is associated with augmented systemic/tissue inflammation and proinflammatory activation of adipose tissue macrophages. | 24703845 |