| ACACA |
| LOCUS ID | 31 | ||||||||||
| GENE_SYMBOL | ACACA | ||||||||||
| GENE NAME | acetyl-CoA carboxyla | ||||||||||
| SYNONYMNS | ACC ACAC ACC1 ACCA ACACAD | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 31015 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylatio |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| 1. ACC1 were found in ovariectomized rats as compared to control group with a significant decrease in PPAR ?, LC3, AMPK and SIRT1. | 31496048 |