| ACAT1 |
| LOCUS ID | 38 | |||||||||||||
| GENE_SYMBOL | ACAT1 | |||||||||||||
| GENE NAME | acetyl-CoA acetyltra | |||||||||||||
| SYNONYMNS | T2, MAT, ACAT, THIL | |||||||||||||
| CHROMOSOME | 11 | |||||||||||||
| HOMOLOGENE ID | 6 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by uriry excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. The use of inhibitors of enzyme acyl-CoAcholesterol acyltransferase (ACAT) seems to be a novel potential approach for a therapeutic treatment of dyslipidaemias and atherosclerosis. | 16222877 |
| Insulin resistance and inflammation | 1. Our work reveals that blocking ACAT1 suppresses diet-induced obesity in part by slowing down monocyte infiltration to WAT as well as by reducing the inflammatory responses of adipose tissue macrophages. | 29533741 |