| ACKR1 |
| LOCUS ID | 2532 | ||||||||||
| GENE_SYMBOL | ACKR1 | ||||||||||
| GENE NAME | atypical chemokine r | ||||||||||
| SYNONYMNS | FY Dfy GPD DARC GpFy CCBP1 CD234 WBCQ1 DARC/ACKR1 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 48067 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Compared to wild-type mice, HFD-fed DARC knockout mice developed glucose intolerance and insulin resistance independent of increases in body weight or adiposity. | 29341885 |