ACKR3
LOCUS ID57007
GENE_SYMBOLACKR3
GENE NAMEatypical chemokine r
SYNONYMNSRDC1 CXCR7 RDC-1 CMKOR1 CXC-R7 CXCR-7 GPR159
CHROMOSOME2
HOMOLOGENE ID22419
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. It is reported that CXCR7 expression is upregulated in adipose tissue, and specifically in ATMs(Adipose tissue macrophages)during obesity.27693695