| ACKR3 |
| LOCUS ID | 57007 | ||||||||||
| GENE_SYMBOL | ACKR3 | ||||||||||
| GENE NAME | atypical chemokine r | ||||||||||
| SYNONYMNS | RDC1 CXCR7 RDC-1 CMKOR1 CXC-R7 CXCR-7 GPR159 | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 22419 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. It is reported that CXCR7 expression is upregulated in adipose tissue, and specifically in ATMs(Adipose tissue macrophages)during obesity. | 27693695 |