| ACSL1 |
| LOCUS ID | 2180 | |||||||||||||
| GENE_SYMBOL | ACSL1 | |||||||||||||
| GENE NAME | acyl-CoA synthetase | |||||||||||||
| SYNONYMNS | ACS1,LACS,FACL1,FACL2,LACS1,LACS2 | |||||||||||||
| CHROMOSOME | 4 | |||||||||||||
| HOMOLOGENE ID | 37561 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. Three SNPs in ACSL1 (rs7681334, rs735949, and rs4862423) are associated with fasting glucose or diabetes status.rs4862423 is associated with subclinical atherosclerosis and coincides with a DHS highly accessible in human heart. SNP rs735949 is in strong linkage disequilibrium with rs745805, significantly associated with ACSL1 levels in skin, suggesting tissue-specific regulatory mechanisms. | 26711138 |
| Insulin resistance and inflammation | 1. Using ACSL-1 siRNA, we further demonstrate that TNF-?-induced inflammatory markers expression in monocytic cells requires ACSL1. | 30845379 |