ACSL1
LOCUS ID2180
GENE_SYMBOLACSL1
GENE NAMEacyl-CoA synthetase
SYNONYMNSACS1,LACS,FACL1,FACL2,LACS1,LACS2
CHROMOSOME4
HOMOLOGENE ID37561
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1. Three SNPs in ACSL1 (rs7681334, rs735949, and rs4862423) are associated with fasting glucose or diabetes status.rs4862423 is associated with subclinical atherosclerosis and coincides with a DHS highly accessible in human heart. SNP rs735949 is in strong linkage disequilibrium with rs745805, significantly associated with ACSL1 levels in skin, suggesting tissue-specific regulatory mechanisms.26711138
Insulin resistance and inflammation1. Using ACSL-1 siRNA, we further demonstrate that TNF-?-induced inflammatory markers expression in monocytic cells requires ACSL1. 30845379