| ADA |
| LOCUS ID | 100 | ||||||||||
| GENE_SYMBOL | ADA | ||||||||||
| GENE NAME | adenosine deaminase | ||||||||||
| SYNONYMNS | ADA1 | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 37249 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine in the purine catabolic pathway. Various mutations have been described for this gene and have been linked to human diseases related to impaired immune function such as severe combined immunodeficiency disease (SCID) which is the result of a deficiency in the ADA enzyme. In ADA-deficient individuals there is a marked depletion of T, B, and NK lymphocytes, and consequently, a lack of both humoral and cellular immunit |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Increased adenosine deaminase (ADA) has been suggested to induce insulin resistance and inflammation.? | 30896318 |