ADA
LOCUS ID100
GENE_SYMBOLADA
GENE NAMEadenosine deaminase
SYNONYMNSADA1
CHROMOSOME20
HOMOLOGENE ID37249
microRNAsNANA
GENE SUMMARY
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine in the purine catabolic pathway. Various mutations have been described for this gene and have been linked to human diseases related to impaired immune function such as severe combined immunodeficiency disease (SCID) which is the result of a deficiency in the ADA enzyme. In ADA-deficient individuals there is a marked depletion of T, B, and NK lymphocytes, and consequently, a lack of both humoral and cellular immunit

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. Increased adenosine deaminase (ADA) has been suggested to induce insulin resistance and inflammation.?30896318