| ADAM10 |
| LOCUS ID | 102 | ||||||||||
| GENE_SYMBOL | ADAM10 | ||||||||||
| GENE NAME | ADAM metallopeptidas | ||||||||||
| SYNONYMNS | RAK, kuz, AD10, AD18, MADM, CD156c, HsT18717 | ||||||||||
| CHROMOSOME | 15 | ||||||||||
| HOMOLOGENE ID | 865 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. regulation of CXCL16, ADAM10 and oxLDL expression may be an early event in the onset of DN and therefore all three proteins may represent potential new targets for diagnosis and therapeutic intervention in DN | 19426159 |