| ADAM28 |
| LOCUS ID | 10863 | ||||||||||
| GENE_SYMBOL | ADAM28 | ||||||||||
| GENE NAME | ADAM metallopeptidas | ||||||||||
| SYNONYMNS | MDCL MDC-L eMDCII ADAM 28 eMDC II | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 40705 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Human ADAM28 expression levels were positively correlated with parameters of the metabolic syndrome. | 23010875 |