| ADH1B |
| LOCUS ID | 125 | |||||||||||||
| GENE_SYMBOL | ADH1B | |||||||||||||
| GENE NAME | alcohol dehydrogenas | |||||||||||||
| SYNONYMNS | ADH2, HEL-S-117 | |||||||||||||
| CHROMOSOME | 4 | |||||||||||||
| HOMOLOGENE ID | 133563 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subuni |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. We speculated that protein kinase C isoforms up-regulated by 4-hydroxynonenal that was detoxified by ALDH2 and ADH2 may account for the long-term development of diabetic nephropathy and severe retinopathy. | 15318096 |
| Neuropathy | 1. As for neuropathy, the frequency of symptomatic neuropathy was higher in patients with inactive ALDH2 and usual ADH2. | 15318096 |