ADORA1
LOCUS ID134
GENE_SYMBOLADORA1
GENE NAMEadenosine A1 recepto
SYNONYMNS RDC7
CHROMOSOME1
HOMOLOGENE ID20165
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript va

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Activation of the adenosine A1 receptor (A1R) inhibits lipolysis in adipocytes and hence reduces the concentration of FFA, which represents a potential target for the development of antilipolytic agents.30905656