| ADORA1 |
| LOCUS ID | 134 | ||||||||||
| GENE_SYMBOL | ADORA1 | ||||||||||
| GENE NAME | adenosine A1 recepto | ||||||||||
| SYNONYMNS | RDC7 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 20165 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript va |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. Activation of the adenosine A1 receptor (A1R) inhibits lipolysis in adipocytes and hence reduces the concentration of FFA, which represents a potential target for the development of antilipolytic agents. | 30905656 |