| ADORA2B |
| LOCUS ID | 136 | ||||||||||
| GENE_SYMBOL | ADORA2B | ||||||||||
| GENE NAME | adenosine A2b recept | ||||||||||
| SYNONYMNS | ADORA2 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 20167 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Diabetes affects the production of adenosine and the expression of A(2B)Rs that stimulate IL-6 and CRP production, insulin resistance, and the association between ADORA2B SNPs and inflammatory markers. | 21270276 |