| AGAP2 |
| LOCUS ID | 116986 | ||||||||||
| GENE_SYMBOL | AGAP2 | ||||||||||
| GENE NAME | ArfGAP with GTPase d | ||||||||||
| SYNONYMNS | PIKE GGAP2 CENTG1 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 86815 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1.Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-? on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses. | 28404596 |