AGAP2
LOCUS ID116986
GENE_SYMBOLAGAP2
GENE NAMEArfGAP with GTPase d
SYNONYMNSPIKE GGAP2 CENTG1
CHROMOSOME12
HOMOLOGENE ID86815
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1.Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-? on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses. 28404596