| Complication | Evidence | PMID |
| Nephropathy | 1. 2184A/G polymorphism in the RAGE gene was significantly associated with diabetic nephropathy in Chinese Han patients with type 2 diabetes. 2. These results suggest that assessment of the combination of NADPH p22phox C242T and RAGE G1704T polymorphisms may be useful in identifying the risk for developing diabetic nephropathy in type 2 diabetic patients. | 26770981 |
| Cardiovascular | 1. It is thus considered that RAGE could be a potential targeting receptor for the prevention and treatment of the development of obesity, beta-cell failure, vascular complications, and inflammation in type 2 diabetes. | 23970880 |
| Retinopathy | 1. Inhibition of AGE formation or blockade of the downstream RAGE signaling is a promising therapeutic strategy for treatment of patients with diabetic retinopathy 2. This is the first study that shows an association between the 2245A allele of the RAGE gene and development of diabetic retinopathy in the Malaysian population. | 16047941 |
| Atherosclerosis | 1.Taken together, these findings establish a new murine model for the study of atherosclerosis in type 2 diabetes and highlight important roles for RAGE in proatherogenic mechanisms in hyperglycemia triggered by insulin resistance. | 16076470 |
| Neuropathy | 1. The findings of this study demonstrate up-regulation of RAGE in skin biopsy samples from patients with diabetic neuropathy, supporting a pathogenic role of RAGE in the development of diabetic neuropathy. | 25324883 |
