| AGTR1 |
| LOCUS ID | 185 | |||||||||||||
| GENE_SYMBOL | AGTR1 | |||||||||||||
| GENE NAME | angiotensin II recep | |||||||||||||
| SYNONYMNS | AT1, AG2S, AT1B, AT1R, AT1AR, AT1BR, AT2R1, HAT1R | |||||||||||||
| CHROMOSOME | 3 | |||||||||||||
| HOMOLOGENE ID | 3556 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardi |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. T allele of ACAC beta and C allele of AGTR1 were found to be significantly associated with proteinuria, a hallmark of DN. We also found significant epistatic interactions between these two genes. TT genotypes of ACAC beta gene and CC genotype of AGTR1 gene confers the risk of DN and both genes had significant epistatic interaction in Asian Indian patients with T2DM. | 23081748 |
| Insulin resistance and inflammation | 1. In the cross-sectional cohort, AGTR1 C allele carriers had higher insulin resistance. | 30920415 |