| AGTRAP |
| LOCUS ID | 57085 | ||||||||||
| GENE_SYMBOL | AGTRAP | ||||||||||
| GENE NAME | angiotensin II recep | ||||||||||
| SYNONYMNS | ATRAP | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 7621 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Results presented in this study suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet-induced visceral obesity and insulin resistance through improvement of adipose inflammation and function via the suppression of overactivation of adipose AT1R signaling. | 28264860 |