| AHRR |
| LOCUS ID | 57491 | ||||||||||
| GENE_SYMBOL | AHRR | ||||||||||
| GENE NAME | aryl-hydrocarbon rec | ||||||||||
| SYNONYMNS | AHH, AHHR, bHLHe77 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 49215 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Altertively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. We identified differential D methylation of 349 CpG sites representing 233 unique genes including TNF, CHI3L1 (also known as YKL-40), CHN2, GIPR, GLRA1, GPX1, AHRR, and BCOR in cases with PDR compared with controls. | 26248552 |