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AHSG |
LOCUS ID | 197 | |||||||||||||||||||
GENE_SYMBOL | AHSG | |||||||||||||||||||
GENE NAME | alpha-2-HS-glycoprot | |||||||||||||||||||
SYNONYMNS | AHS, A2HS, HSGA, FETUA | |||||||||||||||||||
CHROMOSOME | 3 | |||||||||||||||||||
HOMOLOGENE ID | 1225 |
microRNAs | NA | NA |
GENE SUMMARY |
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Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mR. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it par |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. Fetuin-A is demonstrated as a risk factor for both microalbuminuria and reduction of GFR in diabetic nephropathy with the odds ratio of 4.721 (1.881-11.844) and 3. 739 (1.785-7.841), respectively.Collectively, the glycan profiling analysis is useful method to identify the urine biomarkers and fetuin-A is a candidate to predict the progression of diabetic nephropathy. | 24143207 |
Cardiovascular | 1. Fetuin-A has a diagnostic potential as a biomarker for liver dysfunction, cardiovascular diseases and disorders associated with metabolic syndrome. | 25916279 |
Retinopathy | 1. The occurrence and severity of DR is correlated with serum and vitreous fetuin-A concentrations. | 26110737 |
Insulin resistance and Inflammation | 1. we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be associated with insulin resistance but also with fat accumulation in the liver. | 16567827 |