| ALOX5 |
| LOCUS ID | 240 | |||||||||||||
| GENE_SYMBOL | ALOX5 | |||||||||||||
| GENE NAME | arachidonate 5-lipox | |||||||||||||
| SYNONYMNS | 5-LO, 5LPG, LOG5, 5-LOX | |||||||||||||
| CHROMOSOME | 10 | |||||||||||||
| HOMOLOGENE ID | 561 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory an |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. The arachidonate 5-lipoxygenase (ALOX5) pathway has been implicated in chronic inflammatory disease which may be influenced by vitamin D due to vitamin D response elements (VDRE). | 30521849 |
| Insulin resistance and inflammation | 1. ALOX5 and ALOX5AP expression is increased in humans and rodents with obesity and insulin resistance. | 27207555 |