ALOX5AP
LOCUS ID241
GENE_SYMBOLALOX5AP
GENE NAMEarachidonate 5-lipox
SYNONYMNSFLAP
CHROMOSOME13
HOMOLOGENE ID1231
microRNAsNANA
GENE SUMMARY
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding di

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. FLAP antagonist administration decreased proteinuria in glomerulonephritic patients. 2. These suggest a role for FLAP other than the activation of 5-LO, possibly in protein handling, and point to FLAP antagonists as anti-proteinuric agents.12649539
Atherosclerosis1. Polymorphisms within ALOX12, ALOX5, and ALOX5AP are genetically associated with subclinical atherosclerosis and with biomarkers of disease in families with type 2 diabetes.20592751
Insulin resistance and inflammation1. ALOX5AP is present in adipose tissue, where its expression is associated with body weight and HOMA(IR), and may provide a link between adipose tissue, inflammation and insulin resistance.16261187