| ALPK1 |
| LOCUS ID | 80216 | |||||||||||||
| GENE_SYMBOL | ALPK1 | |||||||||||||
| GENE NAME | alpha kinase 1 | |||||||||||||
| SYNONYMNS | FLJ22670, KIAA1527, Lak, lymphocyte alpha-kinase | |||||||||||||
| CHROMOSOME | 4 | |||||||||||||
| HOMOLOGENE ID | 11849 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes an alpha kinase. Mice which were homozygous for disrupted copies of this gene exhibited coordition defects (PMID21208416). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Cardiovascular | 1. ALPK1 and THBS2 may thus be susceptibility loci for CAD and ischemic stroke. | 26137247 |
| Nephropathy | 1. In conclusion, high?glucose stimulation enhances ALPK1 expression in the kidney in vitro and in vivo. Elevated ALPK1 expression up?regulates the renal levels of CCL2 and CCL5 in cultured kidney cell and in mice model. Our data suggest that ALPK1 is a potential mediator for CCL2 and CCL5 chemokines induction involving in ALPK1?mediated accelerated diabetic nephropathies. | 31557402 |