| AMBP |
| LOCUS ID | 259 | ||||||||||
| GENE_SYMBOL | AMBP | ||||||||||
| GENE NAME | alpha-1-microglobuli | ||||||||||
| SYNONYMNS | A1M, HCP, ITI, UTI, EDC1, HI30, ITIL, IATIL, ITILC | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 1234 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteinsalpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a Urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is loca |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Label-free quantitative comparison of DN urinary exosomes vs control group and SRM further validation, resulted in the discovery of a panel of three proteins (AMBP, MLL3 and VDAC1) which changes in DN, opening a new field of research focused to improve diagnosis and follow-up of this pathology. | 24211404 |