| AMH |
| LOCUS ID | 268 | ||||||||||
| GENE_SYMBOL | AMH | ||||||||||
| GENE NAME | anti-Mullerian hormo | ||||||||||
| SYNONYMNS | MIF MIS | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 68060 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian h |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. AMH was directly associated with insulin resistance among obese men [OR 1.08 (95% CI 1.00, 1.15);?P?= 0.046; N = 146], whereas AMH was inversely associated with waist circumference (WC) among obese men [OR 0.95 (95% CI 0.91, 0.99);?P?= 0.049; N = 146]. | 31020056 |