| ANGPT2 |
| LOCUS ID | 285 | |||||||||||||
| GENE_SYMBOL | ANGPT2 | |||||||||||||
| GENE NAME | angiopoietin 2 | |||||||||||||
| SYNONYMNS | ANG2, AGPT2 | |||||||||||||
| CHROMOSOME | 8 | |||||||||||||
| HOMOLOGENE ID | 22401 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. Glycemic control or blocking Ang2/integrin signaling could be a potential therapeutic target to prevent pericyte loss in early diabetic retinopathy. 2. Ang2 is also involved in incipient diabetic retinopathy, as it may cause pericyte loss.These data suggest that Ang2 is involved in pericyte recruitment, and modulates intraretinal, and preretinal vessel formation in the eye under physiological and pathological conditions | 24722242 |
| Insulin resistance and inflammation | 1. The correlations between ANGPT2 and CXCL10, and NAFLD features were dependent on insulin resistance and T2D, but for the other genes the correlation with at least one NAFLD feature remained significant after correcting for the covariates. | 25664838 |