| ANGPTL2 |
| LOCUS ID | 23452 | ||||||||||||||||
| GENE_SYMBOL | ANGPTL2 | ||||||||||||||||
| GENE NAME | angiopoietin-like 2 | ||||||||||||||||
| SYNONYMNS | ARP2, HARP | ||||||||||||||||
| CHROMOSOME | 9 | ||||||||||||||||
| HOMOLOGENE ID | 22695 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The upregulation of ANGPTL2 in diabetic glomerulopathy shows a close relationship to abnormal microvasculature and endothelial inflammation. ANGPTL2 may play an important role in the pathogenesis of diabetic glomerulopathy. | 17347581 |
| Atherosclerosis | 1. Serum ANGPTL2 concentration was significantly and positively associated with carotid atherosclerosis in patients with type 2 diabetes, suggesting that ANGPTL2 may be important in the atherosclerosis in humans. | 25889082 |
| Insulin resistance and inflammation | 1. ANGPTL2 is associated with an increased risk of cardiovascular events and death in diabetic patients. | 27491833 |