| ANGPTL3 |
| LOCUS ID | 27329 | ||||||||||
| GENE_SYMBOL | ANGPTL3 | ||||||||||
| GENE NAME | angiopoietin like 3 | ||||||||||
| SYNONYMNS | ANL3, ANG-5, FHBL2, ANGPT5 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 8499 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. ANGPTL3 is independently and strongly associated with DR progression in all stages. | 29621508 |