ANGPTL3
LOCUS ID27329
GENE_SYMBOLANGPTL3
GENE NAMEangiopoietin like 3
SYNONYMNSANL3, ANG-5, FHBL2, ANGPT5
CHROMOSOME1
HOMOLOGENE ID8499
microRNAsNANA
GENE SUMMARY
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. ANGPTL3 is independently and strongly associated with DR progression in all stages.29621508