| ANGPTL4 |
| LOCUS ID | 51129 | ||||||||||||||||
| GENE_SYMBOL | ANGPTL4 | ||||||||||||||||
| GENE NAME | angiopoietin-like 4 | ||||||||||||||||
| SYNONYMNS | NL2, ARP4, FIAF, HARP, PGAR, HFARP, TGQTL, UNQ171, pp1158, ANGPTL2 | ||||||||||||||||
| CHROMOSOME | 19 | ||||||||||||||||
| HOMOLOGENE ID | 10755 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. The upregulation of ANGPTL2 in diabetic glomerulopathy shows a close relationship to abnormal microvasculature and endothelial inflammation. ANGPTL2 may play an important role in the pathogenesis of diabetic glomerulopathy. | 17347581 |
| Retinopathy | 1. ANGPTL4 was induced by high glucose in RPE cells and exhibited potent angiogenic activity on RE cells. Our are unique and may potentially add a new candidate to the long list of molecules involved in diabetic retinopathy | 23387337 |
| Insulin resistance and inflammation | 1. Detection of inflammatory cytokines suggested that down-regulated ANGPTL4 resulted in increased expressions of inflammatory cytokines and activation of NF-kB pathway. CONCLUSIONS: ANGPTL4 is down-regulated in GDM and may participate in the GDM development by promoting insulin resistance and secretion of inflammatory cytokines. | 30178822 |