| ANXA1 |
| LOCUS ID | 301 | ||||||||||
| GENE_SYMBOL | ANXA1 | ||||||||||
| GENE NAME | annexin A1 | ||||||||||
| SYNONYMNS | ANX1 LPC1 | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 563 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. These data indicate that ANXA1 is an important modulator of adiposity in mice, with female ANXA1 KO mice on Balb/c background being more susceptible to weight gain and diet-induced insulin resistance compared to WT mice | 24312665 |