| AOC2 |
| LOCUS ID | 314 | ||||||||||
| GENE_SYMBOL | AOC2 | ||||||||||
| GENE NAME | amine oxidase, coppe | ||||||||||
| SYNONYMNS | RAO, DAO2 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 56457 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in reti, possibly by degrading the biogenic |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The possibility that semicarbazide-sensitive amine oxidase, by its conversion of endogenous amines like methylamine and aminoacetone into cytotoxic aldehydes, plays a role in the development of microvascular complications in diabetes mellitus, needs further investigation. | 7634751 |