| AOC3 |
| LOCUS ID | 8639 | |||||||||||||
| GENE_SYMBOL | AOC3 | |||||||||||||
| GENE NAME | amine oxidase, coppe | |||||||||||||
| SYNONYMNS | HPAO, SSAO, VAP1, VAP-1 | |||||||||||||
| CHROMOSOME | 17 | |||||||||||||
| HOMOLOGENE ID | 2770 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of th |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. VAP-1 inhibition might be beneficial in the treatment of DR. | 19635478 |
| Insulin resistance and inflammation | 1. VAP-1 has been strongly implicated in several pathological processes, including diabetes, inflammation, hypertension, hepatic steatosis and renal diseases, and is an important disease marker and therapeutic target. | 29364582 |