| APC |
| LOCUS ID | 324 | |||||||||||||
| GENE_SYMBOL | APC | |||||||||||||
| GENE NAME | adenomatous polyposi | |||||||||||||
| SYNONYMNS | GS, DP2, DP3, BTPS2, DP2.5, PPP1R46 | |||||||||||||
| CHROMOSOME | 5 | |||||||||||||
| HOMOLOGENE ID | 30950 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Decreased APC levels in patients with type 2 diabetes may serve as a biomarker to indicate the early development of diabetic nephropathy. | 24660539 |
| Atherosclerosis | 1. These results suggest that decreased APC generation is associated with vascular atherosclerotic changes in Type 2 diabetic patients. | 17971179 |