| API5 |
| LOCUS ID | 8539 | ||||||||||
| GENE_SYMBOL | API5 | ||||||||||
| GENE NAME | apoptosis inhibitor | ||||||||||
| SYNONYMNS | AAC11, AAC-11 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 4809 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic D fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple altertively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes. | 25819896 |